Econazole Induces p53-Dependent Apoptosis and Decreases Metastasis Ability in Gastric Cancer Cells
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چکیده
منابع مشابه
Econazole Nitrate Induces Apoptosis in MCF-7 Cells via Mitochondrial and Caspase Pathways
Econazole nitrate (EN), a synthetic compound, is now in use as a routine antifungal drug. EN was shown to have antitumor effect, the tumor cell killing mechanisms, however, remain unclear. In this research, the apoptosis-inducing effect of EN on MCF-7 cells was investigated. The results showed that EN inhibited the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method ...
متن کاملEconazole Nitrate Induces Apoptosis in MCF-7 Cells via Mitochondrial and Caspase Pathways
Econazole nitrate (EN), a synthetic compound, is now in use as a routine antifungal drug. EN was shown to have antitumor effect, the tumor cell killing mechanisms, however, remain unclear. In this research, the apoptosis-inducing effect of EN on MCF-7 cells was investigated. The results showed that EN inhibited the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method ...
متن کاملLeptadenia pyrotechnica Induces P53-Dependent Apoptosis in Colon Cancer Cells)
Mohammad A Khasawneh1*, Adrian Koch4, Hanan M Elwy2, Alaaeldin A Hamza2,3 and Regine Schneider-Stock4 1Department of Chemistry, Faculty of Science U.A.E. University, Al-Ain, P.O. Box 17551, UAE 2National Organizations of Drug Control and Research, 6 Abu Hazem St., Giza, Egypt 3Department of Biology, Faculty of Science U.A.E. University, Al-Ain, P.O. Box 17551, UAE 4Experimental Tumorpathology, ...
متن کاملUrushiol Induces Apoptosis via a p53-dependent Pathway in Human Gastric Cancer Cells
BACKGROUND Urushiols are mixtures of olefinic catechols which is isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes). The aim of this study was to determine the anticancer effects of urushiol in human gastric adenocarcinoma cell lines. METHODS The cytotoxicity of urushiols was assessed by MTT assays on the two gastric adenocarcinoma cell lines, MKN-45 (wild type of p53) and...
متن کاملeconazole nitrate induces apoptosis in mcf-7 cells via mitochondrial and caspase pathways
econazole nitrate (en), a synthetic compound, is now in use as a routine antifungal drug. en was shown to have antitumor effect, the tumor cell killing mechanisms, however, remain unclear. in this research, the apoptosis-inducing effect of en on mcf-7 cells was investigated. the results showed that en inhibited the proliferation of mcf-7 cells in a time- and dose-dependent manner by mtt method ...
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ژورنال
عنوان ژورنال: Biomolecules & Therapeutics
سال: 2020
ISSN: 1976-9148,2005-4483
DOI: 10.4062/biomolther.2019.201